Dr Erin Dodd

Research Interests: Exploring the mechanism by which NO-sensing FeS cluster proteins detect the small molecule transmitter NO using infrared spectroscopy



Current Position

2017 -	Researcher Co-I / PDRA Department of Chemistry, University of Oxford
Previous Positions
2014 - 2017	Royal Society Newton International Fellow University of East Anglia
2012 - 2013	Postdoctoral Fellow under Prof. Stephen J. Lippard: Chemical crosstalk of NO and H2S in biological systems - exploration of fundamental inorganic chemistry of HSNO and development of fluorescent probes for direct detection of HSNO in cells Massachusetts Institute of Technology
Education
2005 - 2012	PhD (Chemistry) Monomeric and Dimeric Gallium (III) Protoporphyrin IX Species: soluble models for malaria pigment / drug interactions with Prof. D. Scott Bohle, McGill University, Montreal, QC, Canada
1997 - 2002	B.Sc. (Chemistry); B.A. (English literature) Memorial University of Newfoundland, St. John's, NL, Canada
Other Achievements
2015	Marie Curie H2020 IF postdoctoral fellowship (declined)
2009	Sterry Hunt Award for excellence in undergraduate instruction (McGill)
Funding
2017 - 2020	Researcher Co-I: BBSRC: Mechanistic and Structural Insights into NO sensing by Iron-Sulfur Cluster Regulators
Selected Conference Presentations
2018	International Biometals Symposium, Ottawa, ON, Canada "Nitrosylation of [4Fe-4S] clusters: aligning synthetic and biological studies to probe the early stages of the nitrosylation mechanism" (oral)
2018	European Biological Inorganic Chemistry (EuroBIC) Conference, Birmingham, UK - "Nitrosylation of [Fe4S4] clusters: probing the effect of cluster ligand environment" (poster)
2016	Gordon Research Conference: Metallocofactors, Easton, MA, US - "Nitrosylation of [4Fe-4S] clusters: aligning synthetic and biological studies to probe the mechanism of nitrosylation (poster)"
2016	RSC Dalton Meeting, Warwick, UK - "Nitrosylation of [4Fe-4S] clusters: aligning synthetic and biological studies to probe the mechanism of nitrosylation" (oral)
2011	International Conference in Bio-Inorganic chemistry (ICBIC) conference, Vancouver, BC, Canada - "Gallium Analogs of Hemozoin: re-assessing heme self-interactions in biology" (poster)
Selected publications
	Kuter, D. , Suarez, L. , Noll, B. C., Dodd, E. L., Stephens, P. W. and Bohle, D. S., Hydrating the Bispropionate Notch in Malaria Pigment: A New Structural Motif in the Iron(III)(deuteroporphyrin) Dimer. Chem. Eur. J. 2019, 25 (17), 4373 - 4378
	Dodd, E. L., Crack, J. C., Thompson, A. J., Le Brun, N. E. Reactivity of iron-sulfur clusters with nitric oxide. Chapter - in: Rouault, T. (Ed.), Bonomi, F., Ichiye, T., et al. (2017). Iron-Sulfur Clusters in Chemistry and Biology, Volume 1 Characterization, Properties and Applications. Berlin, Boston: De Gruyter
	Volbeda, A., Dodd, E. L., Darnault, C., Crack, J., Renoux, O., Hutchings, M., Le Brun, N. E., Fontecilla-Camps, J. C. (2017). Crystal structures of apo and holo forms of the nitric oxide sensor regulator NsrR reveal the role of the [4Fe-4S] cluster in modulating DNA binding. Nature Communications. 2017, 8, 15052
	Dodd, E. L.; Tazoo, D.; Bohle, D. S. Solution and Solid State Correlations of Antimalarial Drug Actions: NMR and Crystallographic Studies of Drug Interactions with a Heme Model. Inorganic Chemistry 2017, 56 (14), 7803 - 7810
	Dodd, E. L. and D. S. Bohle (2016). Extended structure of indium(III) protoporphyrin IX acetate mimics dimer structure of hematin anhydride. Polyhedron 2016, 108: 36 - 42
	Crack, J. C., Munnoch, J., Dodd, E. L., Knowles, F., Al Bassam, M. M., Kamali, S., Holland, A. A., Cramer, S. P., Hamilton, C. J., Johnson, M. K., Thomson, A. J., Hutchings, M. I., and Le Brun, N. E. NsrR from Streptomyces coelicolor Is a Nitric Oxide-sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Function. Journal of Biological Chemistry 2015, 290(20): 12689 - 12704
	Dodd, E. L., Bohle, D. S. Orienting the Heterocyclic Periphery: A Structural Basis for Chloroquine's Antimalarial Activity. Chemical Communications 2014, 50 (89), 13765 - 13768
	Dodd, E. L., Bohle, D. S., et al. Soluble Diamagnetic Model for Malaria Pigment: Coordination Chemistry of Gallium(III)protoporphyrin-IX. Inorganic Chemistry 2012, 51 (20): 10747 - 10761
	Bohle D. S., Dodd E. L., Stephens, P. W. Structure of malaria pigment and related propanoate-linked metalloporphyrin dimers. Chemistry & Biodiversity 2012, 9 (9): 1891 - 902
	Dodd, E. L. and Bohle, D. S. [Gallium(III) protoporphyrin IX]2: A Soluble Diamagnetic Model for Malaria Pigment. Inorganic Chemistry 2012, 51 (8): 4411 - 4413
	Pinter, T. B. J., Dodd, E. L., et al. Spectroscopic and Theoretical Studies of Ga(III)protoporphyrin-IX and Its Reactions with Myoglobin. Inorganic Chemistry 2012, 51 (6): 3743 - 3753
	Moreau R., Tshikudi Malu D., Dumais M., Dalko E, Gaudreault V., Romero H., Martineau C., Kevorkova O., Dardon J. S., Dodd E. L., Bohle D. S., Scorza T. Alterations in bone and erythropoiesis in hemolytic anemia: comparative study in bled, phenylhydrazine-treated and Plasmodium-infected mice. PloS One 2012. 7 (9): e46101
	Dodd, E. L., Bohle, D. S., et al. Soluble Synthetic Analogues of Malaria Pigment: Structure of Mesohematin Anhydride and its Interaction with Chloroquine in Solution. Angewandte Chemie International Edition 2011, 50(27): 6151 - 6154
	Bourbigot, S., Dodd, E., et al. Antimicrobial peptide RP-1: structure and interactions with anionic versus zwitterionic micelles. Biopolymers 2009, 91(1): 1 - 13