2016 IB Catalst funding
The Vincent group have received major funding from EPSRC via Innovate UK / EPSRC / BBSRC Industrial Biotechnology Catalyst Round 3 (EP/N013514/1
). The project, developing H2
-driven enzyme-catalysed chemical synthesis, started in Jan 2016 with Dr Holly Reeve as Project Manager.
2015 iCASE studentship
Michalis Posidias joined the team to begin his DPhil, his research project looks at operating the enzyme-modified particle system in the reverse direction for H+
recycling to support terminal alcohol oxidation to generate aldehydes. This is funded by a BBSCR iCASE studentship with support from Johnson Matthey Catalysis and Chiral Technologies
2014 Business Interaction Voucher
Work to extend the H2
-driven cofactor recycling system to NADPH recycling for NADPH-dependent enzymes was supported by a Metals in Biology NIBB Business interaction voucher and GSK.
2012 ERC Proof of Concept funding
R&D on this innovation was supported by ERC Proof of Concept Grant 297503 during 2012.
in ChemCommun: Zor, C., Reeve, H.A., Quinson, J., Thompson, L.A., Lonsdale, T.H., Dillon, F., Grobert, N., Vincent K.A., 'H2
-driven Biocatalytic Hydrogenation in Continuous Flow using Enzyme-Modified Carbon Nanotube Columns', Chem. Commun.,
2017, 53, 9839-9841 DOI:10.1039/C7CC04465H
Cover Article in Biochemical Journal:
Reeve, H.A., Ash, P.A., Park, H., Huang, A., Posidias, M., Tomlinson, C., Lenz, O., Vincent, K.A., 'Enzymes as modular catalysts for redox half reactions in H2
-powered chemical synthesis: from biology to technology', Biochemical Journal
, 2017, 474
, 215-230 DOI:10.1042/BCJ20160513
Cover Article in ChemCatChem:
Reeve, H.A., Lauterbach, L., Lenz, O., Vincent, K.A. 'Enzyme-Modified Particles for Selective Bio-Catalytic Hydrogenation via H2
-driven NADH Recycling' ChemCatChem
, 2015, 7
, 21, 3480 - 3487 DOI:10.1002/cctc.201500766
Reeve, H.A., Lauterbach, L., Ash, P.A., Lenz, O., Vincent, K.A., 'A modular
system for regeneration of NAD cofactors using graphite particles modified with
hydrogenase and diaphorase moieties' Chem. Commun.
2012, 48 (10), 1589-1591.
Lauterbach, L., Idris, Z., Vincent, K.A., Lenz, O. 'Catalytic properties of the
isolated diaphorase fragment of the NAD+
from Ralstonia eutropha
' PLoS ONE
, 2011, 6, (10): e25939.
A patent covering the HydRegen technology was filed in 2011.
Publication number: WO2013050760 A2